Semaglutide Side Effects


When Semaglutide or Compounded Semaglutide is used for weight loss, the side effects are similar to its use for type 2 diabetes, but the context and patient expectations may differ. Here’s a focused list of side effects that might be experienced when Semaglutide is used specifically for weight loss:

  1. Gastrointestinal Issues: These are among the most common side effects and include nausea, vomiting, diarrhea, abdominal pain, and constipation. These effects are typically more pronounced at the beginning of treatment and might decrease over time as the body adjusts to the medication.
  2. Appetite Changes: A reduction in appetite is one of the intended effects of Semaglutide to aid in weight loss, but it can also be perceived as an adverse effect if it leads to significant discomfort or if the decrease in appetite is too pronounced.
  3. Hypoglycemia: Although less common in individuals using Semaglutide for weight loss who do not have diabetes, low blood sugar can still occur, especially if the person is using other medications or has intermittent eating patterns.
  4. Pancreatitis: This is a rare but serious side effect, characterized by severe abdominal pain that can radiate to the back and may be accompanied by vomiting.
  5. Gallbladder Problems: Semaglutide has been associated with an increased risk of gallstones and gallbladder inflammation, which can cause abdominal pain, nausea, and vomiting.
  6. Renal Issues: There are reports of acute kidney injury, typically in the context of volume depletion, such as from prolonged nausea, vomiting, and diarrhea.
  7. Allergic Reactions: Rarely, individuals may experience allergic reactions to Semaglutide, presenting as a rash, itching, or, in severe cases, anaphylaxis.
  8. Injection Site Reactions: For those taking the injectable form, local reactions at the injection site can occur, including redness, itching, or swelling.
  9. Fatigue: Some people may experience general tiredness or fatigue when using Semaglutide.
  10. Psychological Effects: Changes in mood or mental health should be monitored, as weight loss and changes in appetite can sometimes impact mental well-being.

It’s crucial for individuals using Semaglutide for weight loss to be under the care of a healthcare provider to monitor for these side effects and adjust the treatment plan as necessary. If any severe or persistent side effects occur, it’s important to consult with a healthcare professional promptly.